Open-label placebos (OLPs) are an inert treatment administered openly and transparently, allowing patients to knowingly receive a placebo while still experiencing therapeutic benefits (eg, pain relief). In this review, we outline methodological considerations for designing and conducting open-label placebo studies in pain research and beyond, providing guidance on control group selection, blinding strategies, and reporting standards - with direct experience in conducting OLP studies from each author. In addition, we gathered insights from the patient advisory board of the transregional Collaborative Research Center (CRC/TRR) 289 “Treatment Expectation” to incorporate patient perspectives on the feasibility and acceptability of OLPs. Read the full paper published in the journal PAIN here.

Huge congrats to Dr. Balint Kincses, who has received the 2026 IFORES Career Kickstart grant for his project titled "Layers of pain: uncovering the mechanisms in the cortical integration of bottom-up and top-down processes in pain perception and its modulation using ultra-high field fMRI". He will conduct his work at the Erwin L. Hahn Institute using 7 Tesla neuroimaging to differentiate the role of different cortical layers.

How does a placebo reduce pain? Our study led by Tamas Spisak suggests that the answer depends on how the placebo effect is induced. We combine brain imaging data from 16 studies involving 409 participants: Verbal suggestions & learning through experience recruit overlapping—but partly distinct—brain mechanisms.

Rather than reflecting inconsistency across studies, these differences provide important clues about the biology of placebo pain relief. The study also highlights the value of pooling participant-level neuroimaging data across labs. By embracing heterogeneity instead of treating it as a problem, we gain a richer understanding of how the brain supports pain relief—ultimately moving toward more personalized treatment approaches.

We are deeply grateful to all our collaborators for their willingness to share data, expertise, & ideas. Their commitment to open, transparent, & reproducible science made it possible to answer a question no single study could have addressed alone. More info: placebo-imaging-consortium.github.io

The research topic in the journal Frontiers in Psychology on "Optimizing the Therapeutic Potential in Clinical Settings: Leveraging Placebos and Mitigating Nocebo Effects" now includes three contributions from our lab! Thanks Frontiers for pushing this important topic!

[1] "Optimized communication during risk disclosure to reduce nocebo headache after lumbar puncture - a study protocol" (Asan et al., 2025)

[2] "From catastrophizing to catalyzing: does pain catastrophizing modulate the beneficial impact of open-label placebos for chronic low back pain?" (Caliskan et al., 2025)

[3] "The association between test anxiety, learning strategies, and open-label placebo effects on academic test performance" (Frisaldi et al., 2025)

Huge congratulations to our (former) medical doctoral student Elif Buse Caliskan, who passed her doctoral defense today with flying colors! She wrote her thesis in the Bingellab on "The role of anxiety in nocebo hyperalgesia and its impact on pain perception". We wish Elif all the best for the next steps in her career!

We are currently looking for support with our experimental studies in Essen, particularly with MRI measurements but also general research assistant tasks. Feel free to download and forward this ad to interested parties here. If you have any questions, feel free to reach out to Katarina Forkmann (katarina.forkmann@uk-essen.de).

Helena Hartmann and colleagues systematically reviewed 50/2060 screened studies that looked at how changing someone’s own pain experience — through substances like opioids, acetaminophen, cannabinoids, placebos, alcohol, or hypnosis — also affects how people feel and respond to others’ emotions and pain. The authors found mixed and inconsistent effects, meaning some types of pain modulation sometimes increased or decreased social cognition abilities, with the most consistent and replicated result being that placebo analgesia reduced empathy for others’ pain. However, because the studies were very different from each other and often had small sample sizes or specific study designs, a lot more work is needed to understand how our own pain influences social feelings and behavior overall. Read the full publication in the journal Pain here.

A new (German) podcast episode from the ERCM Medizin Podcast with Ulrike Bingel talks about the power of expectations, its neurobiological mechanisms, doctor-patient communication and the importance of trust in this relationship! Watch the full episode here.

Today we have something about science communication! This new (German) book is aimed at healthcare professionals, so everyone working with or around patients: How can you use placebo effects when working with patients? How can you harness the power of expectation in patient care? How can you communicate successfully?

Order and read it here as a physical copy or ebook.